Get Antimetabolites in Biochemistry, Biology and Medicine. PDF

By J. Skoda, Peter Langen

ISBN-10: 0080243843

ISBN-13: 9780080243849

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Extra info for Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978

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18, 335 (1958). S. Cohen, J. G. Flaks, H. D. Barner, M. R. Loeb, and S. J. Lichtenstein, The mode of action of 5-fluorouracil and its derivatives, Proc. Natl. Acad. Sci. A. 44, 1004 (1958). Friedkin, and A. Kornberg, The enzymatic conversion of deoxyM. uridylic acid to thymidylic acid and the participation of tetrahydrofolic acid, in The Chemical Basis of Heredity (W. D. McElroy and B. A. R. J. Kent, and C. Heidelberger, Fluorinated pyrimidines, XL. The reduction of 5-fluorouridine 5 -diphosphate by ribonucleotide reductase, Mol.

Cell Tissue Kinet. 4, 297 (1971). 41 INHIBITORS OF THYMIDYLATE SYNTHETASE Daniel V. A. ABSTRACT Inhibition of thymidylate synthetase by 5-substituted-2'-deoxyuridylates has permitted quantitative structure-activity relationships to be established. From this, it was concluded that electron withdrawing 5-substituents enhance binding whereas bulky substituents are detrimental to binding. A number of mechanism-based inhibitors are also described. The 6-position of these 5-substituted-2'-deoxyuridylates reacts with a nucleophilic catalyst of the enzyme to form covalently bound 5,6-dihydropyrimidines.

18. 19. 20. 21. 22. 23. 24. casei, Biochemistry 10, 88 (1971). R. P. Leary, and R. L. Kisliuk, Crystalline thymidylate synthetase from dichloromethotrexate resistant Lactobacillus casei, Prep. Biochem. 1, 47 (1971). M. Y. Lorenson, G. F. Maley, and F. Maley, The purification and properties of thymidylate synthetase from chick embryo extracts, J. Biol. Chem. 242, 3332 (1967). B. J. -C. Cheng, Human thymidylate synthetase derived from blast cells of patients with acute myelocytic leukemia, J. Biol.

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Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978 by J. Skoda, Peter Langen


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