Get Angiogenesis: From the Molecular to Integrative Pharmacology PDF

By Michael E. Maragoudakis (auth.), Michael E. Maragoudakis (eds.)

ISBN-10: 1461368952

ISBN-13: 9781461368953

ISBN-10: 1461542219

ISBN-13: 9781461542216

Proceedings of the fifth Biannual foreign assembly on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece.
Angiogenesis, as a enormously advanced organic procedure, has challenged researchers from all uncomplicated clinical disciplines, together with pharmacology, biochemistry, body structure, embryology and anatomy. the importance of this phenomenon for the research of sickness states has additionally clinicians from a couple of professional fields. This multidisciplinary paintings displays the expansion of knowledge of options akin to angiogenesis established remedy, the big healing and advertisement capability of which has attracted significant study and funding lately. This quantity, which goals to bridge the distance among uncomplicated and scientific technique and knowing, offers the main up to date advancements during this field.

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RESULTS Angiogenic action of thrombin in the chick chorioallantoic membrane system (CAM) and in the Matrigel system in vivo. Using these systems we have shown previously that thrombin is a potent promoter of angiogenesis. Both a and y-thrombin promote angiogenesis to the same extent. Because y-thrombin can not form fibrin, therefore, blood clotting, we conclude that the action of thrombin on angiogenesis is independent of fibrin formation. This effect of thrombin is specific (hirudin or heparin abolish this effect) and dose dependent.

1). Blot: a-Tiel Tie Tie Vector Tie Tie ltIffie Tek 105a-pY Figure 1. Expression of Tie-l endodornain in yeast. Western blots of whole celllysates from yeast expressing various Tie-l (Tie) or Tie-2 (Tek) constructs including a fusion protein incorporating the RI dirnerization (RIlTie) 38 As found in the endothelial cell background, expression of the Tie-l tyrosine kinase fails to induce tyrosine phosphorylation of either cellular proteins or itself. In contrast the intracellular domain of Tie-2 induces marked tyrosine phosphorylation in this system (Fig 1).

M. ,1996, Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, AI. J. Bioi. Chern. 271: 27201-4. 29. , Sullivan A. , Isner J. , et al. ,1997, Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals [published erratum appears in J Mol Cell Cardiol1998 Apr;30(4):897]. J. Mol. Cell. Cardiol. 29: 1321-30. ON THE MECHANISM(S) OF THROMBIN INDUCED ANGIOGENESIS Michael E.

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Angiogenesis: From the Molecular to Integrative Pharmacology by Michael E. Maragoudakis (auth.), Michael E. Maragoudakis (eds.)


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