By Irwin M. Chaiken
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80, 1018-1022(1983). CELLULAR RECOGNITION: IMMOBILIZED SYNTHETIC AND NATURAL GLYCOCONJUGATES ELICIT SPECIFIC CELL ADHESION AND POST-ADHESION RESPONSES^ Ronald L. Sohnaar Department of Pharmacology and Experimental Therapeutics The Johns Hopkins university School of Medicine Baltimore, Maryland I. CELL-CELL RECOGNITION: SIGNIFICANCE AND IN VITRO STUDIES Important cellular processes such as growth, motility, differentiation and death are controlled, in part, by extra cellular signals received at the cell surface ( 1 ) .
REFERENCES 1. 2. 3. 4. 5. 6. 7. 8. 9. , Symp. Soc. Dev. Biol. 35, 3 (1978). , "The Cell Surface Mediator of Developmental Processes, Academic Press, New York, (1980). , Yale J. Biol. Med. 19, 235 (1947). L. Dehaan and H. Ursprung, e d s . ) , p . 1 6 1 . Holt, Rinehart and Winston, New York, (1965). , J. Exp. Zool. 5, 245 ( 1 9 0 7 ) . , J. Exp. Zool. 128, 53 (1955). , J. Anat. 86, 287 ( 1 9 5 2 ) . , Proc. Natl. Acad. Sci. USA 43, 184 ( 1 9 5 7 ) . , J. Cell Biol. 74, 858 (1977). , and McLoon, S .
There appears to be a spontaneous, pH-dependent fusion of the viral and host cell membranes which subsequently allows the nucleocapsid to be injected into the cytoplasm. Whether this mechanism is also common for nonenveloped viruses remains to be determined, but certainly in the latter category there are some medically important viruses such as influenza, and this mechanism suggests possible new routes for selectively interfering with the viral replication process. In fact, 36 PEDRO CUATRECASAS the anti-influenzal agent, amantadine, is capable of neutralizing the endosomal and lysosomal acidity, and this may be the mechanism by which it affects influenza virus replication (14).
Affinity Chromatography and Biological Recognition by Irwin M. Chaiken